Rare coding variants in 35 genes associate with circulating lipid levels—A multi-ancestry analysis of 170,000 exomes
By: Hindy G., Dornbos P., Chaffin M.D., Liu D.J., Wang M., Selvaraj M.S., Zhang D., Park J., Aguilar-Salinas C.A., Antonacci-Fulton L., Ardissino D., Arnett D.K., Aslibekyan S., Atzmon G., Ballantyne C.M., Barajas-Olmos F., Barzilai N., Becker L.C., Bielak L.F., Bis J.C., Blangero J., Boerwinkle E., Bonnycastle L.L., Bottinger E., Bowden D.W., Bown M.J., Brody J.A., Broome J.G., Burtt N.P., Cade B.E., Centeno-Cruz F., Chan E., Chang Y.-C., Chen Y.-D.I., Cheng C.-Y., Choi W.J., Chowdhury R., Contreras-Cubas C., Córdova E.J., Correa A., Cupples L.A., Curran J.E., Danesh J., de Vries P.S., DeFronzo R.A., Doddapaneni H., Duggirala R., Dutcher S.K., Ellinor P.T., Emery L.S., Florez J.C., Fornage M., Freedman B.I., Fuster V., Garay-Sevilla M.E., García-Ortiz H., Germer S., Gibbs R.A., Gieger C., Glaser B., Gonzalez C., Gonzalez-Villalpando M.E., Graff M., Graham S.E., Grarup N., Groop L.C., Guo X., Gupta N., Han S., Hanis C.L., Hansen T., He J., Heard-Costa N.L., Hung Y.-J., Hwang M.Y., Irvin M.R., Islas-Andrade S., Jarvik G.P., Kang H.M., Kardia S.L.R., Kelly T., Kenny E.E., Khan A.T., Kim B.-J., Kim R.W., Kim Y.J., Koistinen H.A., Kooperberg C., Kuusisto J., Kwak S.H., Laakso M., Lange L.A., Lee J., Lee J., Lee S., Lehman D.M., Lemaitre R.N., Linneberg A., Liu J., Loos R.J.F., Lubitz S.A., Lyssenko V., Ma R.C.W., Martin L.W., Martínez-Hernández A., Mathias R.A., McGarvey S.T., McPherson R., Meigs J.B., Meitinger T., Melander O., Mendoza-Caamal E., Metcalf G.A., Mi X., Mohlke K.L., Montasser M.E., Moon J.-Y., Moreno-Macías H., Morrison A.C., Muzny D.M., Nelson S.C., Nilsson P.M., O’Connell J.R., Orho-Melander M., Orozco L., Palmer C.N.A., Palmer N.D., Park C.J., Park K.S., Pedersen O., Peralta J.M., Peyser P.A., Post W.S., Preuss M., Psaty B.M., Qi Q., Rao D.C., Redline S., Reiner A.P., Revilla-Monsalve C., Rich S.S., Samani N., Schunkert H., Schurmann C., Seo D., Seo J.-S., Sim X., Sladek R., Small K.S., So W.Y., Stilp A.M., Tai E.S., Tam C.H.T., Taylor K.D., Teo Y.Y., Thameem F., Tomlinson B., Tsai M.Y., Tuomi T., Tuomilehto J., Tusié-Luna T., Udler M.S., van Dam R.M., Vasan R.S., Viaud Martinez K.A., Wang F.F., Wang X., Watkins H., Weeks D.E., Wilson J.G., Witte D.R., Wong T.-Y., Yanek L.R., Kathiresan S., Rader D.J., Rotter J.I., Boehnke M., McCarthy M.I., Willer C.J., Natarajan P., Flannick J.A., Khera A.V., Peloso G.M., AMP-T2D-GENES, Myocardial Infarction Genetics Consortium, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, NHLBI TOPMed Lipids Working Group
Published in: American Journal of Human Genetics
SDGs : SDG 03 | Units: Natural Sciences | Time: 2022 | Link
Description: Large-scale gene sequencing studies for complex traits have the potential to identify causal genes with therapeutic impl (more…)
