Anti-inflammation properties of fruiting bodies and submerged cultured mycelia of culinary-medicinal higher basidiomycetes mushrooms

By: Chien R.-C., Lin L.-M., Chang Y.-H., Lin Y.-C., Wu P.-H., Asatiani M.D., Wasser S.G., Krakhmalnyi M., Agbarya A., Wasser S.P., Mau J.-L.
Published in: International Journal of Medicinal Mushrooms
SDGs : SDG 03  |  Units:   | Time: 2016 |  Link
Description: This research shows the phenolic composition and anti-inflammation properties of fruiting bodies and mycelia of 15 strai ns of 12 species of higher Basidiomycetes medicinal mushrooms. In this research, 15 extracts were prepared and their effects on inflammation-related mediators in RAW 264.7 cells were evaluated. In the extracts, amounts of total phenols ranged from 8.47 to 70.32 gallic acid equivalents mg/g and amounts of flavonoids ranged from 0.13 to 15.21 rutin equivalents mg/g. The production of nitric oxide, tumor necrosis factor-α, and interleukin-6 was decreased at different levels by these extracts, whereas the production of interleukin-10 was increased by 6 of the extracts. Overall, Cordyceps militaris fruiting bodies, Grifola frondosa fruiting bodies, and Ophiocordyceps sinensis mycelia might be used to ameliorate inflammatory responses. © 2016 Begell House, Inc.