
Rare coding variants in 35 genes associate with circulating lipid levels—A multi-ancestry analysis of 170,000 exomes
מאת: Hindy G., Dornbos P., Chaffin M.D., Liu D.J., Wang M., Selvaraj M.S., Zhang D., Park J., Aguilar-Salinas C.A., Antonacci-Fulton L., Ardissino D., Arnett D.K., Aslibekyan S., Atzmon G., Ballantyne C.M., Barajas-Olmos F., Barzilai N., Becker L.C., Bielak L.F., Bis J.C., Blangero J., Boerwinkle E., Bonnycastle L.L., Bottinger E., Bowden D.W., Bown M.J., Brody J.A., Broome J.G., Burtt N.P., Cade B.E., Centeno-Cruz F., Chan E., Chang Y.-C., Chen Y.-D.I., Cheng C.-Y., Choi W.J., Chowdhury R., Contreras-Cubas C., Córdova E.J., Correa A., Cupples L.A., Curran J.E., Danesh J., de Vries P.S., DeFronzo R.A., Doddapaneni H., Duggirala R., Dutcher S.K., Ellinor P.T., Emery L.S., Florez J.C., Fornage M., Freedman B.I., Fuster V., Garay-Sevilla M.E., García-Ortiz H., Germer S., Gibbs R.A., Gieger C., Glaser B., Gonzalez C., Gonzalez-Villalpando M.E., Graff M., Graham S.E., Grarup N., Groop L.C., Guo X., Gupta N., Han S., Hanis C.L., Hansen T., He J., Heard-Costa N.L., Hung Y.-J., Hwang M.Y., Irvin M.R., Islas-Andrade S., Jarvik G.P., Kang H.M., Kardia S.L.R., Kelly T., Kenny E.E., Khan A.T., Kim B.-J., Kim R.W., Kim Y.J., Koistinen H.A., Kooperberg C., Kuusisto J., Kwak S.H., Laakso M., Lange L.A., Lee J., Lee J., Lee S., Lehman D.M., Lemaitre R.N., Linneberg A., Liu J., Loos R.J.F., Lubitz S.A., Lyssenko V., Ma R.C.W., Martin L.W., Martínez-Hernández A., Mathias R.A., McGarvey S.T., McPherson R., Meigs J.B., Meitinger T., Melander O., Mendoza-Caamal E., Metcalf G.A., Mi X., Mohlke K.L., Montasser M.E., Moon J.-Y., Moreno-Macías H., Morrison A.C., Muzny D.M., Nelson S.C., Nilsson P.M., O'Connell J.R., Orho-Melander M., Orozco L., Palmer C.N.A., Palmer N.D., Park C.J., Park K.S., Pedersen O., Peralta J.M., Peyser P.A., Post W.S., Preuss M., Psaty B.M., Qi Q., Rao D.C., Redline S., Reiner A.P., Revilla-Monsalve C., Rich S.S., Samani N., Schunkert H., Schurmann C., Seo D., Seo J.-S., Sim X., Sladek R., Small K.S., So W.Y., Stilp A.M., Tai E.S., Tam C.H.T., Taylor K.D., Teo Y.Y., Thameem F., Tomlinson B., Tsai M.Y., Tuomi T., Tuomilehto J., Tusié-Luna T., Udler M.S., van Dam R.M., Vasan R.S., Viaud Martinez K.A., Wang F.F., Wang X., Watkins H., Weeks D.E., Wilson J.G., Witte D.R., Wong T.-Y., Yanek L.R., Kathiresan S., Rader D.J., Rotter J.I., Boehnke M., McCarthy M.I., Willer C.J., Natarajan P., Flannick J.A., Khera A.V., Peloso G.M., AMP-T2D-GENES, Myocardial Infarction Genetics Consortium, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, NHLBI TOPMed Lipids Working Group
פורסם ב: American Journal of Human Genetics
תיאור: Large-scale gene sequencing studies for complex traits have the potential to identify causal genes with therapeutic impl המשך…