New locus for skin intrinsic fluorescence in type 1 diabetes also associated with blood and skin glycated proteins

מאת: Roshandel D., Klein R., Klein B.E.K., Wolffenbuttel B.H.R., Van Der Klauw M.M., Van Vliet-Ostaptchouk J.V., Atzmon G., Ben-Avraham D., Crandall J.P., Barzilai N., Bull S.B., Canty A.J., Hosseini S.M., Hiraki L.T., Maynard J., Sell D.R., Monnier V.M., Cleary P.A., Braffett B.H., Paterson A.D.
פורסם ב: Diabetes
תיאור: Skin fluorescence (SF) noninvasively measures advanced glycation end products (AGEs) in the skin and is a risk indicatorfor diabetes complications. N-acetyltransferase 2 (NAT2) is the only known locus influencing SF. We aimed to identify additional genetic loci influencing SF in type 1 diabetes (T1D) through a meta-analysis of genomewide association studies (N = 1,359) including Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) and Wisconsin Epidemiologic Study of Diabetic Retinopathy (WESDR). A locus on chromosome 1, rs7533564 (P = 1.9 × 10-9), was associated with skin intrinsic fluorescence measured by SCOUT DS (excitation 375 nm, emission 435-655 nm), which remained significant after adjustment for time-weighted HbA1c (P = 1.7 × 10-8). rs7533564 was associated with mean HbA1c in meta-analysis (P = 0.0225), mean glycated albumin (P = 0.0029), and glyoxal hydroimidazolones (P = 0.049), an AGE measured in skin biopsy collagen, in DCCT. rs7533564 was not associated with diabetes complications in DCCT/EDIC or with SF in subjects without diabetes (nondiabetic [ND]) (N = 8,721). In conclusion, we identified a new locus associated with SF in T1D subjects that did not show similar effect in ND subjects, suggesting a diabetes-specific effect. This association needs to be investigated in type 2 diabetes. © 2016 by the American Diabetes Association.
SDGs : SDG 03  |  יחידות: מדעי הטבע  | מועד: 2016 |  קישור