Holocaust exposure and late-life cognitive performance in men with coronary heart disease

מאת: Weinstein G., Lutski M., Keinan-Boker L., Goldbourt U., Tanne D.
פורסם ב: Journal of Psychiatric Research
תיאור: Background: Holocaust victims experienced extreme physical and mental stress that could lead to prolonged deficits in psychological and physiological well-being. We aimed to examine whether exposure to Holocaust conditions is associated with cognitive function and decline in a sample of old male adults with coronary heart disease (CHD). Methods: The sample included 346 individuals with CHD who participated in a clinical trial in 1990–1997 (mean age 56.7 ± 6.5 y). During 2004–2008 (mean age 71.8 ± 6.5 y) and 2011–2013 (mean age 77.1 ± 6.4 y) participants underwent computerized cognitive assessments. Exposure to Holocaust conditions was based on self-report at the second assessment. Linear regression and mixed-effect models were conducted to evaluate the associations between Holocaust survivorship and subsequent cognitive performance and rate of cognitive decline. Results: Forty-Three participants (12%) survived concentration camps/ghettos, 69 (20%) were Holocaust survivors who escaped concentration camps/ghettos, and 234 (68%) were not Holocaust survivors. After adjustment for potential confounders, concentration camp/ghetto survivors had poorer global cognitive performance and poorer attention (β = −3.90; 95%CI: 7.11;-0.68 and β = −4.11; 95%CI: 7.83;-0.38, respectively) compared to individuals who were not exposed to Holocaust conditions. Additionally, participants who reported being at concentration camps/ghettoes had increased cognitive decline in global performance and executive function (β = −0.19; 95%CI: 0.37;-0.008 and β = −0.29; 95%CI: 0.53;-0.06, respectively) compared to participants who were not Holocaust survivors. Lastly, those who were Holocaust survivors but not in concentration camps/ghettos had greater decline in attention (β = −0.11; 95%CI: 0.21;-0.01). Discussion: Exposure to Holocaust conditions in early-life may be linked with poorer cognitive function and greater cognitive decline decades later in old-adults with CHD. © 2020 Elsevier Ltd
SDGs : SDG 03  |  יחידות: מדעי הרווחה והבריאות  | מועד: 2021 |  קישור