Transposon-triggered innate immune response confers cancer resistance to the blind mole rat

מאת: Zhao Y., Oreskovic E., Zhang Q., Lu Q., Gilman A., Lin Y.S., He J., Zheng Z., Lu J.Y., Lee J., Ke Z., Ablaeva J., Sweet M.J., Horvath S., Zhang Z., Nevo E., Seluanov A., Gorbunova V.
פורסם ב: Nature Immunology
תיאור: Blind mole rats (BMRs) are small rodents, characterized by an exceptionally long lifespan (>21 years) and resistance toboth spontaneous and induced tumorigenesis. Here we report that cancer resistance in the BMR is mediated by retrotransposable elements (RTEs). Cells and tissues of BMRs express very low levels of DNA methyltransferase 1. Following cell hyperplasia, the BMR genome DNA loses methylation, resulting in the activation of RTEs. Upregulated RTEs form cytoplasmic RNA–DNA hybrids, which activate the cGAS–STING pathway to induce cell death. Although this mechanism is enhanced in the BMR, we show that it functions in mice and humans. We propose that RTEs were co-opted to serve as tumor suppressors that monitor cell proliferation and are activated in premalignant cells to trigger cell death via activation of the innate immune response. Activation of RTEs is a double-edged sword, serving as a tumor suppressor but contributing to aging in late life via the induction of sterile inflammation. © 2021, The Author(s), under exclusive licence to Springer Nature America, Inc.
SDGs : SDG 03  |  יחידות:   | מועד: 2021 |  קישור