Ophthalmic Assessment in Patients With Darier Disease

מאת: Hammad H., Adler E., Yeshurun A., Abayev L., Vered S., Briscoe D., Ziv M., Dodiuk-Gad R.P.
פורסם ב: American Journal of Ophthalmology
תיאור: Purpose: To assess the prevalence of ophthalmic findings in patients with Darier disease, an autosomal dominant geneticskin disorder, in an effort to evaluate the need for eye examinations in the management of the disease. Design: Prospective observational case series. Methods: Thirty-six individuals with Darier disease were evaluated by both ocular assessment questionnaire and a comprehensive ophthalmic examination (visual acuity, refraction, external examination, and slit-lamp examination) with emphasis on the eyelids, conjunctiva, and cornea. In addition, questionnaire-based medical interview and skin examination were conducted. Results: According to the medical questionnaire, 39% of patients reported eye problems, 36% dry eye, and 42% eye fatigue after prolonged reading. Ocular examination revealed Darier disease lesions on the eyelids in 55% of the patients, blepharitis in 44%, conjunctival hyperemia in 28%, and short tear film break-up time in 83%. There was no significant relationship between any of these ophthalmic findings and systemic retinoid therapy, sex, or age. Conclusions: The high prevalence of blepharitis and dry eye highlights the importance of ophthalmologic evaluation of patients with Darier disease. © 2021 Elsevier Inc.
SDGs : SDG 03  |  יחידות:   | מועד: 2021 |  קישור