Behavioral and neural stability of attention bias to threat in healthy adolescents

מאת: White L.K., Britton J.C., Sequeira S., Ronkin E.G., Chen G., Bar-Haim Y., Shechner T., Ernst M., Fox N.A., Leibenluft E., Pine D.S.
פורסם ב: NeuroImage
תיאור: Considerable translational research on anxiety examines attention bias to threat and the efficacy of attention trainingin reducing symptoms. Imaging research on the stability of brain functions engaged by attention bias tasks could inform such research. Perturbed fronto-amygdala function consistently arises in attention bias research on adolescent anxiety. The current report examines the stability of the activation and functional connectivity of these regions on the dot-probe task. Functional magnetic resonance imaging (fMRI) activation and connectivity data were acquired with the dot-probe task in 39 healthy youth (f = 18, Mean Age = 13.71 years, SD = 2.31) at two time points, separated by approximately nine weeks. Intraclass-correlations demonstrate good reliability in both neural activation for the ventrolateral PFC and task-specific connectivity for fronto-amygdala circuitry. Behavioral measures showed generally poor test-retest reliability. These findings suggest potential avenues for future brain imaging work by highlighting brain circuitry manifesting stable functioning on the dot-probe attention bias task. © 2016 Elsevier Inc.
SDGs : SDG 03  |  יחידות: מדעי החברה  | מועד: 2016 |  קישור