A neural circuit for comorbid depressive symptoms in chronic pain

מאת: Zhou W., Jin Y., Meng Q., Zhu X., Bai T., Tian Y., Mao Y., Wang L., Xie W., Zhong H., Zhang N., Luo M.-H., Tao W., Wang H., Li J., Li J., Qiu B.-S., Zhou J.-N., Li X., Xu H., Wang K., Zhang X., Liu Y., Levin G.R., Xu L., Zhang Z.
פורסם ב: Nature Neuroscience
תיאור: Comorbid depressive symptoms (CDS) in chronic pain are a common health problem, but the neural circuit mechanisms underlying these symptoms remain unclear. Here we identify a novel pathway involving 5-hydroxytryptamine (5-HT) projections from the dorsal raphe nucleus (5-HTDRN) to somatostatin (SOM)-expressing and non-SOM interneurons in the central nucleus of the amygdala (CeA). The SOMCeA neurons project directly to the lateral habenula, an area known involved in depression. Inhibition of the 5-HTDRN→SOMCeA pathway produced depression-like behavior in a male mouse model of chronic pain. Activation of this pathway using pharmacological or optogenetic approaches reduced depression-like behavior in these mice. Human functional magnetic resonance imaging data showed that compared to healthy controls, functional connectivity between the CeA-containing centromedial amygdala and the DRN was reduced in patients with CDS but not in patients in chronic pain without depression. These findings indicate that a novel 5-HTDRN→SOMCeA→lateral habenula pathway may mediate at least some aspects of CDS. © 2019, The Author(s), under exclusive licence to Springer Nature America, Inc.
SDGs : SDG 03  |  יחידות:   | מועד: 2019 |  קישור